In 2021, IUCN launched the IUCN Flagship Report Series, to help demonstrate the importance of conserving nature for human well-being and all life on Earth. This report, the second in the series, focuses on agriculture and nature. The interactions, synergies, and tradeoffs between the two sit at the heart of the 2030 Agenda for Sustainable Development, which calls for ending hunger and ensuring food security while also mandating the protection and restoration of nature. Whether the two can be achieved simultaneously, and if so how, are crucial questions for humanity and our planet. IUCN therefore explores the positive and negative relationships between agriculture and nature conservation and mobilises new modelling approaches to examine both imperatives within a range of realistic policies.