Tropical forests are on the front line of climate change and human sustainability challenges, being key environments in discussions of the “Anthropocene” and some of the most threatened land-based habitats on the face of the Earth. However, while it has been acknowledged that 21st-century anthropogenic alterations to tropical forests have the potential to set off major earth systems feedbacks on regional to global scales, there has been less discussion on how past human activities may have had similar impacts. Indeed, difficult working conditions, poor preservation, and environmental determinism have traditionally led to these habitats being framed as “blanks” on the map of human history. In this Special Feature, we draw on multidisciplinary contributions from archaeology, history, paleoecology, climate science, and Indigenous traditional knowledge to explore our species’ interaction with tropical forests across space and through time.