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Despite a wealth of biodiversity laws operating at every scale of governance, the world’s rich diversity of plants, animals, and ecosystems is disappearing. The effects of land use change and over-extraction are exacerbated by changing weather patterns and more extreme climate events such as floods and wildfires. The Global Biodiversity Framework, adopted by 196 national governments in December 2022, must be implemented in a way that ensures that the world can protect nature wherever it will survive, including across political borders and in unfamiliar combinations.