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With their rich repertoire of anti-infective substances, medicinal plants have always been key in the human fight to survive pathogens and parasites. The search for herbal drugs with novel structures and effects is still one of the great challenges of natural product research today. Scientists from Leipzig University (UL), the Leibniz Institute of Plant Biochemistry (IPB) and the German Centre for Integrative Biodiversity Research (iDiv) now report a way to simplify the search for bioactive natural compounds using data analyses on the phylogenetic relationships, spatial distribution and secondary metabolites of plants.